Chen Shao-Ru, Qiu Hong-Cong, Hu Yang, Wang Ying, Wang Yi-Tao
State Key Laboratory of Quality Research in Chinese Medicine and Institute of Chinese Medical Sciences, University of Macau, Avenida da Universidade, Taipa, Macao, SAR, China.
Guangxi Institute of Traditional Medical and Pharmaceutical Sciences and Guangxi Key Laboratory of Traditional Chinese Medicine Quality Standards, Nanning, 530022, China.
Phytother Res. 2016 Jun;30(6):863-77. doi: 10.1002/ptr.5594. Epub 2016 Feb 15.
Hepatocellular carcinoma (HCC) is a common malignant cancer and is the third leading cause of death worldwide. Effective treatment of this disease is limited by the complicated molecular mechanism underlying HCC pathogenesis. Thus, therapeutic options for HCC management are urgently needed. Targeting the Wnt/β-catenin, Hedgehog, Notch, and Hippo-YAP signaling pathways in cancer stem cell development has been extensively investigated as an alternative treatment. Herbal medicine has emerged as an initiative therapeutic option for HCC management because of its multi-level, multi-target, and coordinated intervention effects. In this article, we summarized the recent progress and clinical benefits of targeting the above mentioned signaling pathways and using natural products such as herbal medicine formulas to treat HCC. Proving the clinical success of herbal medicine is expected to deepen the knowledge on herbal medicine efficiency and hasten the adoption of new therapies. Copyright © 2016 John Wiley & Sons, Ltd.
肝细胞癌（HCC）是一种常见的恶性肿瘤，是全球第三大死亡原因。该疾病的有效治疗受到HCC发病机制复杂分子机制的限制。因此，迫切需要针对HCC治疗的选择。作为一种替代治疗方法，针对癌症干细胞发育中的Wnt/β-连环蛋白、Hedgehog、Notch和Hippo-YAP信号通路进行了广泛研究。由于其多层次、多靶点和协同干预作用，草药已成为HCC治疗的一种主动治疗选择。在本文中，我们总结了针对上述信号通路以及使用天然产物如草药配方治疗HCC的最新进展和临床益处。证明草药的临床成功有望加深对草药疗效的认识，并加速新疗法的采用。版权所有©2016约翰威立父子有限公司。
