Stewart K G, Rowbottom S J, Aitken A W, Rajendram S, Sudhaman D A
Department of Anaesthetics, Grantham Hospital, Hong Kong.
Anaesth Intensive Care. 1990 Feb;18(1):11-4. doi: 10.1177/0310057X9001800103.
In a single-blind controlled study, forty children with congenital heart disease were premedicated with oral trimeprazine 3 mg/kg and either intramuscular morphine 0.1 mg/kg or oral ketamine 10 mg/kg. Cardiovascular and respiratory effects of premedication and degree of sedation induced were similar in the two groups of patients. Oral ketamine is a safe and effective premedicant in this group of patients.
在一项单盲对照研究中，40名先天性心脏病患儿接受口服三甲丙嗪3毫克/千克以及肌肉注射吗啡0.1毫克/千克或口服氯胺酮10毫克/千克进行术前用药。两组患者术前用药的心血管和呼吸效应以及所诱导的镇静程度相似。口服氯胺酮在这类患者中是一种安全有效的术前用药。
