Phillips G H, Mian T, Becker U, Stone P A, Jones H M
Royal Gwent Hospital, Newport.
Anaesthesia. 1990 Oct;45(10):870-2. doi: 10.1111/j.1365-2044.1990.tb14575.x.
One hundred children who presented for minor general surgical procedures were randomly assigned to receive one of two oral premedications. Those in group A (n = 50) were given 3 mg/kg of trimeprazine and those in group B (n = 50) a mixture of trimeprazine 1.0 mg/kg, droperidol 0.15 mg/kg and methadone 0.08 mg/kg. Patients in group B were more likely to be asleep on arrival in the anaesthetic room (p less than 0.02) and were less likely to be distressed at induction of anaesthesia (p less than 0.02). Thiopentone requirements were less in group B (p less than 0.001). The incidence of side effects was similar in the two groups. It is concluded that the mixture produces more satisfactory sedation than trimeprazine.
一百名接受小型普通外科手术的儿童被随机分配接受两种口服术前用药中的一种。A组（n = 50）给予3mg/kg的异丙嗪，B组（n = 50）给予1.0mg/kg异丙嗪、0.15mg/kg氟哌利多和0.08mg/kg美沙酮的混合物。B组患者在到达麻醉室时更易入睡（p<0.02），且在麻醉诱导时痛苦程度更低（p<0.02）。B组硫喷妥钠需求量更少（p<0.001）。两组副作用发生率相似。结论是该混合物产生的镇静效果比异丙嗪更令人满意。
