Wang Jun-Li, Xia Jin, Wang Ju-Fen, Luo Chun, Liang Zong-An
Department of Respiratory, West China Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2011 Jul;42(4):535-9.
To identify risk factors of obstructive sleep apnea hypopnea syndrome (OSAHS) in female patients, and assess its treatment and health-related quality of life (HRQoL) of the patients.
One hundred and ninety three female patients undergoing polysomnography whith sleep breath disorders were recruited and divided into non-OSAHS group and OSAHS group. Age, body mass index (BMI), and prevalence of menopause and hypertension were compared between the two groups. The associations of those variables with apnea hypopnea index (AHI) and lowest pulse oxygen saturation (LSpO2) were analysed. The treatment of OSAHS and its impact on HRQoL assessed by the Calgary quality of life index (SAQLI) were evaluated.
The OSAHS group had greater mean age, BMI, and prevalence of menopause and hypertension than the non-OSAHS group (P<0.05). Those variables were significantly correlated with AHI and LSpO2 (P<0.05). Weight control and positional therapy were the most common treatment for sleep breath disorders. Weight loss and continuous positive airway pressure improved the Epworth sleep scale (ESS) of the patients with OSAHS significantly (P<0.05). But positional therapy made no difference (P>0.05). The ESS of the 32.5% of patients who did not undergo any treatment was worsened during the same period of time (P<0.05). No differences were found in the scores of the four domains of SAQLI between the two groups (P>0.05). The stepwise multiple regression analysis identified Pittsburgh sleep quality index (PSQI), ESS and AHI as independent predictors for the total score of SAQLI (P<0.05).
Older age, greater BMI, menopause and hypertension are risk factors of OSAHS in female patients. OSAHS was not well managed in female patients. PSQI, ESS and AHI can be used as predictors for HRQoL.
识别女性阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者的危险因素，并评估其治疗情况及与健康相关的生活质量（HRQoL）。
招募193例接受多导睡眠监测且存在睡眠呼吸障碍的女性患者，分为非OSAHS组和OSAHS组。比较两组患者的年龄、体重指数（BMI）、绝经及高血压患病率。分析这些变量与呼吸暂停低通气指数（AHI）和最低脉搏血氧饱和度（LSpO2）的相关性。评估OSAHS的治疗及其对通过卡尔加里生活质量指数（SAQLI）评估的HRQoL的影响。
OSAHS组的平均年龄、BMI、绝经及高血压患病率均高于非OSAHS组（P<0.05）。这些变量与AHI和LSpO2显著相关（P<0.05）。体重控制和体位治疗是睡眠呼吸障碍最常见的治疗方法。体重减轻和持续气道正压通气显著改善了OSAHS患者的爱泼沃斯思睡量表（ESS）评分（P<0.05）。但体位治疗无差异（P>0.05）。32.5%未接受任何治疗的患者在同一时期ESS评分恶化（P<0.05）。两组SAQLI四个领域的得分无差异（P>0.05）。逐步多元回归分析确定匹兹堡睡眠质量指数（PSQI）、ESS和AHI为SAQLI总分的独立预测因素（P<0.05）。
年龄较大、BMI较高、绝经和高血压是女性OSAHS患者的危险因素。女性OSAHS患者的病情管理不佳。PSQI、ESS和AHI可作为HRQoL的预测指标。
