柏林问卷在阻塞性睡眠呼吸暂停低通气综合征筛查中的应用

[Application of Berlin questionnaire in the screening of obstructive sleep apnea hypopnea syndrome].

作者信息

Lü Xiang-pei, Zhang Cheng, Ma Jing, Su Li, Jia Peng, Luo Yi-ping, Wei Shu-min, Wang Guang-fa

机构信息

Department of Respiratory Medicine, Peking University First Hospital, Beijing, China.

出版信息

Zhonghua Jie He He Hu Xi Za Zhi. 2011 Jul;34(7):515-9.

PMID:22041777

Abstract

OBJECTIVE

To investigate the value of Berlin questionnaire in screening obstructive sleep apnea hypopnea syndrome (OSAHS) among Chinese.

METHODS

A total of 302 cases with suspected OSAHS were referred to our sleep laboratory. The Berlin questionnaire scores and polysomnography (PSG) monitoring data were analyzed. According to the Berlin questionnaire score, the patients were divided into high and lower risk groups for OSAHS. In terms of the PSG monitoring results, the patients were classified into non-OSAHS, mild, moderate and severe OSAHS groups. The age, gender, apnea hypopnea index (AHI), body mass index, and the Berlin questionnaire (BQ) result were compared among the 4 groups. The correlation of Berlin questionnaire result with age, AHI, the lowest SpO2 (LSpO2) and microarousal index (MAI) were analyzed.

RESULTS

There were significant differences in the Berlin questionnaire results among non-OSAHS and the other 3 groups (χ(2) = 13.961, 8.466, 42.156, P < 0.0083); and between the severe OSAHS and the other 2 groups (χ(2) = 9.439, 11.162, P < 0.0083). There was no statistical difference between the mild and moderate groups (P > 0.0083). The ratio of the high BQ risk patients had an increasing tendency as the severity of OSAHS was increased (χ(2) = 34.211, P < 0.01). The Berlin questionnaire results showed a positive correlation with age, AHI or MAI (r = 0.125, 0.346, 0.198, all P < 0.05, respectively) but a negative correlation with LSpO2 (r = -0.371, P < 0.01). The Berlin questionnaire results showed no correlation with gender (P > 0.05). The sensitivity and the specificity of the Berlin questionnaire in predicting sleep apnea were 0.71 and 0.72, respectively.

CONCLUSIONS

With the moderate sensitivity and the specificity, the Berlin questionnaire has some value in screening patients with OSAHS. However, it is not correlated with the severity of OSAHS in Chinese patients. Thus Berlin questionnaire has limited value in the screening of OSAHS among Chinese.

摘要

目的

探讨柏林问卷在中国人群中筛查阻塞性睡眠呼吸暂停低通气综合征（OSAHS）的价值。

方法

共302例疑似OSAHS患者被转诊至我院睡眠实验室。分析柏林问卷得分及多导睡眠图（PSG）监测数据。根据柏林问卷得分，将患者分为OSAHS高风险组和低风险组。依据PSG监测结果，将患者分为非OSAHS组、轻度OSAHS组、中度OSAHS组和重度OSAHS组。比较4组患者的年龄、性别、呼吸暂停低通气指数（AHI）、体重指数及柏林问卷（BQ）结果。分析柏林问卷结果与年龄、AHI、最低血氧饱和度（LSpO2）及微觉醒指数（MAI）的相关性。

结果

非OSAHS组与其他3组在柏林问卷结果上存在显著差异（χ(2)=13.961、8.466、42.156；P<0.0083）；重度OSAHS组与其他2组之间也存在显著差异（χ(2)=9.439、11.162；P<0.0083）。轻度组与中度组之间无统计学差异（P>0.0083）。随着OSAHS严重程度增加，高BQ风险患者的比例呈上升趋势（χ(2)=34.211；P<0.01）。柏林问卷结果与年龄、AHI或MAI呈正相关（r=0.125、0.346、0.198，均P<0.05），但与LSpO2呈负相关（r=-0.371；P<0.01）。柏林问卷结果与性别无相关性（P>0.05）。柏林问卷预测睡眠呼吸暂停的敏感度和特异度分别为0.71和0.72。