Mandal B K, Ironside A G, Brennand J
Br Med J. 1979 Mar 3;1(6163):586-7. doi: 10.1136/bmj.1.6163.586.
Twelve consecutive patients with enteric fever entered a trial of 14 days' treatment with mecillinam. Only three patients became afebrile within three days; four continued unimproved with fever and toxaemia for seven to nine days, when treatment was changed to chloramphenicol with good results. In one case the fever did not settle until the 13th day, and five days later the patient had a clinical relapse. Although all organisms recovered were fully sensitive to mecillinam, this drug is not an effective or consistent treatment for enteric fever.
12例连续的伤寒患者进入了一项使用美西林进行14天治疗的试验。只有3例患者在3天内退热；4例患者持续发热且有中毒症状，无改善，持续7至9天，之后改用氯霉素治疗，效果良好。有1例患者直到第13天才退热，5天后该患者出现临床复发。尽管所有分离出的菌株对美西林均完全敏感，但该药并非治疗伤寒的有效或可靠药物。
