Poleshchuk N N, Rytik P G, Guzov S A, Kvacheva Z B, Grigor'ev D G, Cherstvoĭ E D
Arkh Patol. 1990;52(1):31-6.
The role of astrocytes in pathogenesis of Creutzfeld-Jakob disease (CJD), one of the slow virus infections of human central nervous system caused by an unconventional virus (prion) has been studied. Histological and ultrastructural examinations of the brain of both dead people and experimentally infected guinea pigs, combined with the data on morphofunctional state of infected monolayer glial culture analysis have shown astrocytes, as well as neurons, to be target-cells for the causative agent of the disease. The astrocyte changes observed were evaluated as proliferative-degenerative ones with the activation prevailing over the cell destruction. It was determined that both fibrous and protoplasmic astrocytes are sensitive to the cell-destructive effect of the CJD agent. Only few astrocytes possess phagocytic activity against the background of CNS degenerative changes in CJD. It is supposed that activated astrocytes are involved in new intercellular reactions, this involvement aggravating the pathological process.
星形胶质细胞在克雅氏病（CJD）发病机制中的作用已得到研究，CJD是由一种非常规病毒（朊病毒）引起的人类中枢神经系统慢病毒感染之一。对死者和实验感染豚鼠大脑进行的组织学和超微结构检查，结合对感染单层神经胶质细胞培养物形态功能状态的分析数据表明，星形胶质细胞以及神经元都是该疾病病原体的靶细胞。观察到的星形胶质细胞变化被评估为增殖 - 退行性变化，激活作用超过细胞破坏作用。已确定纤维型和原浆型星形胶质细胞对CJD病原体的细胞破坏作用均敏感。在CJD中枢神经系统退行性变化的背景下，只有少数星形胶质细胞具有吞噬活性。据推测，活化的星形胶质细胞参与新的细胞间反应，这种参与加剧了病理过程。
