Miyakawa T, Katsuragi S, Koga Y, Moriyama S
Clin Neuropathol. 1986 Jul-Aug;5(4):146-52.
The initial stage of status spongiosus in Ammon's horn of two brains with panencephalopathic type of Creutzfeldt-Jakob disease (PE-CJD) was examined electron microscopically. The results obtained in this examination were as follows: initial formation of large vacuoles or cavities seemed to be the result of distension within cell processes, mainly astrocytes, and these vacuoles and cavities might gradually form status spongiosus. A very important finding in the present study was that all kinds of glial cells showed degenerative changes. It is concluded that glial insufficiency might be one of the pathogenetic mechanisms effective in panencephalopathic Creutzfeldt-Jakob disease.
对两例全脑型克雅氏病（PE-CJD）患者海马角海绵状状态的初始阶段进行了电子显微镜检查。本次检查结果如下：大空泡或腔隙的初始形成似乎是细胞突起（主要是星形胶质细胞）内扩张的结果，这些空泡和腔隙可能逐渐形成海绵状状态。本研究中一个非常重要的发现是所有类型的神经胶质细胞均出现了退行性变化。得出的结论是，神经胶质细胞功能不足可能是全脑型克雅氏病有效的发病机制之一。
