Liberski P P, Yanagihara R, Gibbs C J, Gajdusek D C
Department of Oncology, School of Medicine, Lodz, Poland.
Neuropatol Pol. 1991;29(1-2):1-17.
Ultrastructural findings in mice terminally affected with the Fujisaki strain of Creutzfeldt-Jakob disease virus are reported. Spongiform vacuolation, extensive myelin and axonal lesions and neuroaxonal dystrophy accompanied by abundant astrocytic gliosis comprise the pattern of the pathological changes at the ultrastructural level. Neuronal intranuclear inclusions and swelling of the astrocytic and dendritic processes were unspecific findings also observed in control animals.
报道了感染克雅氏病病毒藤崎株的终末期小鼠的超微结构研究结果。海绵状空泡形成、广泛的髓鞘和轴突病变以及伴有大量星形胶质细胞增生的神经轴突营养不良构成了超微结构水平上的病理变化模式。神经元核内包涵体以及星形胶质细胞和树突状突起肿胀是在对照动物中也观察到的非特异性发现。
