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Synthesis and pharmacological screening of new angiotensin converting enzyme inhibitors.

作者信息

Gubert S, Braso M A, Sacristán A, Ortiz J A

机构信息

Centro de Investigacion Grupo Ferrer, Juan de Sada, Barcelona, Spain.

出版信息

Farmaco. 1990 Jan;45(1):59-79.

PMID:2186741
Abstract

We report the preparation of a series of eight L-alanyl-L-proline derivatives and four L-proline derivatives. Their pharmacological activity as antihypertensive agents was examined with reference to changes in the contractile response to angiotensin I (AI), bradykinine (BK) and angiotensin II (AII). Compounds 1g, 1h and 2c were the most powerful when compared with known angiotensin-converting inhibitors such as captopril and enalapril, and were selected for further pharmacological study.

摘要

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