依那普利的脯氨酰衍生物作为潜在的血管紧张素转换酶抑制剂。
Prolyl derivatives of enalapril as potential angiotensin converting enzyme inhibitors.
作者信息
Ciabatti R, Tarzia G, Battaglia F, Barone D, Baldoli E
机构信息
Merrell - Dow Research Institute - Lepetit Research Center - Gerenzano (Va), Italy.
出版信息
Farmaco Sci. 1988 Dec;43(12):989-1003.
PMID:2854788
Abstract
The synthesis of a new class of potential angiotensin converting enzyme (ACE) inhibitors, analogs of enalapril, is reported. In these molecules the C-terminal amino acidic sequence Ala-Pro of enalapril was replaced by the sequence Pro-Pro. The compounds were tested both in vitro and in vivo. They showed no in vivo activity but only a week in vitro inhibitory activity.
摘要
据报道，合成了一类新型的潜在血管紧张素转换酶（ACE）抑制剂，即依那普利的类似物。在这些分子中，依那普利的C末端氨基酸序列Ala-Pro被Pro-Pro序列所取代。这些化合物在体外和体内均进行了测试。它们在体内没有活性，但在体外仅具有微弱的抑制活性。
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