Leonard E J, Yoshimura T
Laboratory of Immunobiology, National Cancer Institute, FCRF, Frederick, MD 21701.
Immunol Today. 1990 Mar;11(3):97-101. doi: 10.1016/0167-5699(90)90035-8.
During the past three years great advances have been made in the chemistry and biology of chemoattractants for human leukocytes. Two chemoattractant cytokines have been isolated, sequenced and cloned, each with distinctive leukocyte attractant specificity. Monocyte chemoattractant protein 1 (MCP-1), the subject of this review by Edward Leonard and Teizo Yoshimura, is secreted by PHA-stimulated mononuclear cells and can be identified by northern blotting in response to LPS or PHA. It attracts monocytes but not neutrophils. In contrast, neutrophil attractant/activation protein (NAP-1) (also known as interleukin 8 (IL-8)) attracts and activates human neutrophils but it is not a chemoattractant for human monocytes. Based on amino acid sequence analysis, each of these attractants has been assigned to one of two distinct families of cytokines that are thought to participate in host defense and inflammatory responses.
在过去三年中，人类白细胞趋化因子的化学和生物学研究取得了巨大进展。两种趋化因子细胞因子已被分离、测序和克隆，每种都具有独特的白细胞吸引特异性。单核细胞趋化蛋白1（MCP-1），是爱德华·伦纳德和吉村哲三这篇综述的主题，由PHA刺激的单核细胞分泌，可通过Northern印迹法在对LPS或PHA的反应中鉴定出来。它吸引单核细胞，但不吸引中性粒细胞。相比之下，中性粒细胞趋化因子/激活蛋白（NAP-1）（也称为白细胞介素8（IL-8））吸引并激活人类中性粒细胞，但它不是人类单核细胞的趋化因子。基于氨基酸序列分析，这些趋化因子中的每一种都被归入两个不同的细胞因子家族之一，这两个家族被认为参与宿主防御和炎症反应。
