Ahmad Tauqeer, AbouHaidar Mounir, Hefferon Kathleen L
Cell and Systems Biology, University of Toronto, Toronto, Canada M5G 3B2.
Recent Pat DNA Gene Seq. 2011 Dec;5(3):202-13. doi: 10.2174/187221511797636275.
Improved knowledge of the molecular biology of viruses, including recent gains in virus sequence data analysis, has greatly contributed to recent innovations in medical diagnostics, therapeutics, drug development and other related areas. Virus sequences have been used for the development of vaccines and antiviral agents to block the spread of viral infections, as well as to target and battle chronic diseases such as cancer. Virus sequences are now routinely employed in a wide array of RNA silencing technologies. Viruses can also be engineered into expression vectors which in turn can be used as protein production platforms as well as delivery vehicles for gene therapies. This review article outlines a number of patents that have been recently issued with respect to virus sequence data and describes some of their biotechnological applications.
对病毒分子生物学的深入了解，包括近期在病毒序列数据分析方面取得的进展，极大地推动了医学诊断、治疗、药物研发及其他相关领域的创新。病毒序列已被用于开发疫苗和抗病毒药物，以阻断病毒感染的传播，同时也用于靶向和对抗诸如癌症等慢性疾病。病毒序列如今在广泛的RNA沉默技术中得到常规应用。病毒还可被改造为表达载体，进而用作蛋白质生产平台以及基因治疗的递送载体。本文综述了近期发布的一些与病毒序列数据相关的专利，并描述了它们的一些生物技术应用。
