Venkataraman Srividhya, Ahmad Tauqeer, AbouHaidar Mounir G, Hefferon Kathleen L
Cell and Systems Biology, University of Toronto, Toronto, ON M5G 3B2. Canada.
Recent Pat Biotechnol. 2017;11(2):141-151. doi: 10.2174/1872208311666170301103722.
In consideration of recent developments in understanding the genomics and proteomics of viruses, the use of viral DNA / RNA sequences as well as their gene expression schemes, have found new in-roads towards the prognosis and therapy of diseases. Correspondingly, the sphere of the patenting scenario has expanded significantly.
The current review addresses patented inventions concerning the use of virus sequences as gene silencing machineries and inventions concerning the generation and application of viral sequences as expression vectors. Furthermore, this review also discusses the employment of these patents for clinical, agricultural and biotechnological applications.
Considering these objectives, the Delphion Research Intellectual Property Network database was searched using keywords such as "gene silencing", "engineered viruses" and "expression vectors" and descriptions of recent patents on the said topics were discussed.
Despite several recent advances in the use of viruses as disease therapy vehicles and biotechnological vectors, these developments have yet to be proven effective in practice, in clinical and field trials.
鉴于在理解病毒基因组学和蛋白质组学方面的最新进展，病毒DNA/RNA序列及其基因表达模式的应用在疾病的预后和治疗方面找到了新的途径。相应地，专利申请的范围也显著扩大。
本综述探讨了有关将病毒序列用作基因沉默机制的专利发明，以及有关病毒序列作为表达载体的产生和应用的发明。此外，本综述还讨论了这些专利在临床、农业和生物技术应用中的使用情况。
考虑到这些目标，使用“基因沉默”、“工程病毒”和“表达载体”等关键词在德尔菲昂研究知识产权网络数据库中进行了检索，并讨论了近期关于上述主题的专利描述。
尽管最近在将病毒用作疾病治疗载体和生物技术载体方面取得了一些进展，但这些进展在临床和田间试验的实际应用中尚未得到证实。
