Taaning Ellen Birkerod Morling, Kjeldsen-Kragh Jens, Hedegaard Morten, Hegaard Hanne Kristine, Henriksen Tine Brink, Hvas Anne-Mette, Kjærgaard Hanne, Rasmussen Ole Bredahl
Klinisk Immunologisk Afdeling, Vævstypelaboratoriet, Rigshospitalet, Tagensvej 20, 2200 København N, Denmark.
Ugeskr Laeger. 2011 Aug 22;173(34):2041-4.
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) may lead to intracranial haemorrhage (ICH) resulting in neurological damage or death. In FNAIT, transplacental maternal antibodies cause destruction of fetal platelets. Maternal immunisation occurs to fetal human platelet antigens (HPAs) inherited from the father. In the absence of screening the diagnosis often relies on a serious incident in a previous pregnancy or in a newborn sibling. Thus, a future reduction in the risk of ICH depends on prospective large trials to evaluate different diagnostic, treatment, and prevention strategies.
胎儿和新生儿同种免疫性血小板减少症（FNAIT）可能导致颅内出血（ICH），进而造成神经损伤或死亡。在FNAIT中，经胎盘的母体抗体导致胎儿血小板被破坏。母体针对从父亲遗传而来的胎儿人类血小板抗原（HPA）发生免疫反应。若未进行筛查，诊断通常依赖于前次妊娠或新生儿同胞中发生的严重事件。因此，未来降低ICH风险取决于评估不同诊断、治疗和预防策略的前瞻性大型试验。
