Mannuss Anja, Trapp Oliver, Puchta Holger
Botanical Institute II, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Biochim Biophys Acta. 2012 Feb;1819(2):154-65. doi: 10.1016/j.bbagrm.2011.08.003. Epub 2011 Aug 16.
To deal with different kinds of DNA damages, there are a number of repair pathways that must be carefully orchestrated to guarantee genomic stability. Many proteins that play a role in DNA repair are involved in multiple pathways and need to be tightly regulated to conduct the functions required for efficient repair of different DNA damage types, such as double strand breaks or DNA crosslinks caused by radiation or genotoxins. While most of the factors involved in DNA repair are conserved throughout the different kingdoms, recent results have shown that the regulation of their expression is variable between different organisms. In the following paper, we give an overview of what is currently known about regulating factors and gene expression in response to DNA damage and put this knowledge in context with the different DNA repair pathways in plants. This article is part of a Special Issue entitled: Plant gene regulation in response to abiotic stress.
为应对不同类型的DNA损伤，存在多种修复途径，这些途径必须精心协调以确保基因组稳定性。许多在DNA修复中发挥作用的蛋白质参与多种途径，并且需要受到严格调控，以执行有效修复不同类型DNA损伤（如由辐射或基因毒素导致的双链断裂或DNA交联）所需的功能。虽然参与DNA修复的大多数因素在不同生物界中是保守的，但最近的研究结果表明，它们的表达调控在不同生物体之间存在差异。在接下来的论文中，我们概述了目前已知的应对DNA损伤的调控因子和基因表达情况，并将这些知识与植物中的不同DNA修复途径相结合。本文是名为“植物对非生物胁迫的基因调控”的特刊的一部分。
