Division of Neurosurgery, Toronto Western Hospital, Toronto, Ontario, Canada.
Prog Brain Res. 2011;194:83-95. doi: 10.1016/B978-0-444-53815-4.00015-7.
There are a number of emerging surgical indications for deep brain stimulation. We have shown that modulation of activity within motor, mood, and cognitive circuits has beneficial effects in patients with Parkinson's disease, treatment-resistant depression, and perhaps Alzheimer's type dementia. We review the rationale, safety, and efficacy for each of these indications, focusing on disease mechanisms and relevant data that are necessary to document therapeutic value in each case. The review closes with some thoughts on possible future directions for deep brain stimulation. It is likely that applications for deep brain stimulation will continue to expand as accumulating data establish its safety and efficacy profile in these and other conditions.
有许多新兴的手术适应证适用于深部脑刺激。我们已经表明，在帕金森病、治疗抵抗性抑郁症患者中，调节运动、情绪和认知回路中的活动具有有益的效果，也许对阿尔茨海默病型痴呆也有效果。我们回顾了这些适应证的基本原理、安全性和有效性，重点是疾病机制和在每种情况下记录治疗价值所需的相关数据。这篇综述以对深部脑刺激可能的未来方向的一些思考结束。随着越来越多的数据证实深部脑刺激在这些及其他疾病中的安全性和有效性，其应用可能会继续扩大。
