Department of Physiology, Groupe de Recherche sur le Système Nerveux Central, Faculty of Medicine, Université de Montréal, SensoriMotor Rehabilitation Research Team of the Canadian Institute for Health Research, Montréal, Québec, Canada.
Prog Brain Res. 2011;194:191-202. doi: 10.1016/B978-0-444-53815-4.00007-8.
It is well established that a spinal circuitry can generate locomotor movements of the hindlimbs in absence of descending supraspinal inputs. This is based, among others, on the observation that after a complete spinalization, cats can walk with the hindlimbs on a treadmill. Does this spinal pattern generator (CPG) also participate in the recovery of locomotion after a partial spinal cord lesion (SCI)? After such SCI, functional reorganization can occur spontaneously along the whole neuraxis, namely the spinal cord circuitry below the lesion (CPG) and in supraspinal structures still partially connected to the spinal cord. This review focuses mainly on the capacity of the spinal and supraspinal structures to reorganize spontaneously after incomplete SCI in animals (rats and cats). BMI approaches to foster recovery of functions after various types of SCI should take into account these changes at the various levels of the CNS.
众所周知，在没有来自中枢神经系统的下行输入的情况下，脊髓回路可以产生后肢的运动。这一观点的依据之一是，在完全脊髓切断后，猫可以在跑步机上用后肢行走。这种脊髓模式发生器（CPG）是否也参与了部分脊髓损伤（SCI）后的运动恢复？SCI 后，整个神经系统（包括损伤以下的脊髓回路（CPG）和与脊髓部分连接的中枢神经系统结构）可以自发地发生功能重组。这篇综述主要关注动物（大鼠和猫）不完全 SCI 后脊髓和中枢神经系统结构自发重组的能力。促进各种类型 SCI 后功能恢复的 BMI 方法应该考虑到中枢神经系统各个水平的这些变化。
