Groupe de Recherche sur le Système Nerveux Central, Department of Physiology, and Multidisciplinary Team in Locomotor Rehabilitation of the Canadian Institutes for Health Research, Université de Montréal, Montreal H3C 3J7, Canada.
Annu Rev Neurosci. 2011;34:413-40. doi: 10.1146/annurev-neuro-061010-113746.
After spinal cord injury (SCI), various sensorimotor functions can recover, ranging from simple spinal reflexes to more elaborate motor patterns, such as locomotion. Locomotor recovery after complete spinalization (complete SCI) must depend on the presence of spinal circuitry capable of generating the complex sequential activation of various leg muscles. This is achieved by an intrinsic spinal circuitry, termed the central pattern generator (CPG), working in conjunction with sensory feedback from the legs. After SCI, different changes in cellular and circuit properties occur spontaneously and can be promoted by pharmacological, electrical, or rehabilitation strategies. After partial SCI, hindlimb locomotor recovery can result from regeneration or sprouting of spared pathways, but also from mechanisms observed after complete SCI, namely changes within the intrinsic spinal circuitry and sensory inputs.
脊髓损伤 (SCI) 后，各种感觉运动功能可以恢复，从简单的脊髓反射到更复杂的运动模式，如运动。完全截瘫（完全性 SCI）后的运动恢复必须依赖于存在能够产生各种腿部肌肉复杂顺序激活的脊髓回路。这是通过内在的脊髓回路实现的，称为中枢模式发生器（CPG），与腿部的感觉反馈协同工作。SCI 后，细胞和电路特性会自发发生不同的变化，并可通过药理学、电刺激或康复策略来促进这些变化。在部分性 SCI 后，后肢运动恢复可能来自于保留通路的再生或发芽，但也可能来自于完全性 SCI 后观察到的机制，即内在脊髓回路和感觉输入内的变化。
