Montagna W, Carlisle K
Oregon Regional Primate Research Center, Beaverton 97006.
Br J Dermatol. 1990 Apr;122 Suppl 35:61-70. doi: 10.1111/j.1365-2133.1990.tb16127.x.
As average life expectancy is increasing, the ageing of skin presents a growing problem for dermatologists. When considering ageing it is important to distinguish between the effects of true biological ageing and environmental factors, such as exposure to sun. Epidermal changes associated with ageing involve the flattening of its underside, a reduction in the number of Langerhans cells and of melanocytes, and a decline in the number of melanosomes synthesized, leading to reduced pigmentation. Dermal changes involve a reduction in the collagenous and elastic fibres, fibroblasts, mast cells and macrophages, and dilation of the lymphatic channels. The number of hair follicles declines with age, but their structure remains unchanged. Ageing does not affect the sebaceous glands, but some changes occur in the exocrine sweat glands.
随着平均预期寿命的增加，皮肤老化给皮肤科医生带来了日益严重的问题。在考虑皮肤老化时，区分真正的生物老化和环境因素（如日晒）的影响非常重要。与老化相关的表皮变化包括其基底的扁平化、朗格汉斯细胞和黑素细胞数量的减少，以及合成的黑素小体数量的下降，导致色素沉着减少。真皮变化包括胶原纤维和弹性纤维、成纤维细胞、肥大细胞和巨噬细胞数量的减少，以及淋巴管扩张。毛囊数量随年龄增长而减少，但其结构保持不变。老化不影响皮脂腺，但外分泌汗腺会发生一些变化。
