Liver Unit, Hospital General, Universitario Valle Hebron, Paseo Valle Hebron 119, Barcelona 08035, Spain.
Clin Liver Dis. 2011 Aug;15(3):473-82. doi: 10.1016/j.cld.2011.05.007. Epub 2011 Jun 14.
Twenty-five years have passed since interferon-α was first used in the treatment of chronic hepatitis C infection, and even now it remains an essential part of the standard of care for this condition. At present, the recommended treatment is a combination of pegylated interferon and ribavirin A. There have been enormous advances in our understanding of the mechanisms through which interferon works and in identifying factors related to the response to this treatment. Even with the development of new protease inhibitors, it is likely that interferon will remain an essential component of hepatitis C treatment.
自干扰素-α首次用于治疗慢性丙型肝炎感染以来，已经过去了 25 年，即使是现在，它仍然是该疾病治疗标准的重要组成部分。目前，推荐的治疗方法是聚乙二醇干扰素和利巴韦林联合治疗。我们对干扰素作用机制的理解以及对与这种治疗反应相关的因素的认识都取得了巨大的进展。即使开发了新的蛋白酶抑制剂，干扰素也可能仍然是丙型肝炎治疗的重要组成部分。
