Generation of cells that ignore the effects of PIP3 on cytoskeleton.
作者信息
Tang Ming, Iijima Miho, Devreotes Peter
出版信息
Cell Cycle. 2011 Sep 1;10(17):2817-8. doi: 10.4161/cc.10.17.16744.
Abstract
摘要
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Mol Biol Cell. 2011 Feb 15;22(4):437-47. doi: 10.1091/mbc.E10-06-0522. Epub 2010 Dec 17.
2
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis.在细胞前沿，不依赖磷脂酰肌醇-3,4,5-三磷酸（PIP3）激活雷帕霉素靶蛋白复合物2（TorC2）和蛋白激酶B（PKB）介导趋化作用。
Curr Biol. 2008 Jul 22;18(14):1034-43. doi: 10.1016/j.cub.2008.06.068.
3
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42.PTEN介导的磷酸肌醇顶端分选通过Cdc42控制上皮形态发生。
Cell. 2007 Jan 26;128(2):383-97. doi: 10.1016/j.cell.2006.11.051.
4
DOCK2 is a Rac activator that regulates motility and polarity during neutrophil chemotaxis.DOCK2是一种Rac激活剂，在中性粒细胞趋化过程中调节运动性和极性。
J Cell Biol. 2006 Aug 28;174(5):647-52. doi: 10.1083/jcb.200602142.
5
Temporal and spatial regulation of phosphoinositide signaling mediates cytokinesis.磷酸肌醇信号传导的时空调节介导胞质分裂。
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6
In vivo analysis of 3-phosphoinositide dynamics during Dictyostelium phagocytosis and chemotaxis.盘基网柄菌吞噬作用和趋化作用过程中3-磷酸肌醇动力学的体内分析。
J Cell Sci. 2004 Dec 15;117(Pt 26):6497-509. doi: 10.1242/jcs.01579. Epub 2004 Nov 30.
7
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Living with lethal PIP3 levels: viability of flies lacking PTEN restored by a PH domain mutation in Akt/PKB.在致死性磷脂酰肌醇-3,4,5-三磷酸（PIP3）水平下存活：通过Akt/蛋白激酶B（PKB）中的pleckstrin同源（PH）结构域突变恢复缺乏磷酸酶及张力蛋白同源物（PTEN）的果蝇的生存能力。
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