Wu C-Y, Lin M-W, Wu D-C, Huang Y-B, Huang H-T, Chen C-L
Department of Biological Science, National Sun Yat-sen University, Kaohsiung, Taiwan; Doctoral Degree Program in Marine Biotechnology, National Sun Yat-sen University and Academia Sinica, Kaohsiung, Taiwan.
Br J Pharmacol. 2014 Dec;171(24):5541-54. doi: 10.1111/bph.12777. Epub 2014 Nov 24.
Reorganization of the actin cytoskeleton is essential for cell motility and chemotaxis. Actin-binding proteins (ABPs) and membrane lipids, especially phosphoinositides PI(4,5)P2 and PI(3,4,5)P3 are involved in the regulation of this reorganization. At least 15 ABPs have been reported to interact with, or regulated by phosphoinositides (PIPs) whose synthesis is regulated by extracellular signals. Recent studies have uncovered several parallel intracellular signalling pathways that crosstalk in chemotaxing cells. Here, we review the roles of ABPs and phosphoinositides in chemotaxis and cell migration.
This article is part of a themed section on Cytoskeleton, Extracellular Matrix, Cell Migration, Wound Healing and Related Topics. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue-24.
肌动蛋白细胞骨架的重组对于细胞运动和趋化性至关重要。肌动蛋白结合蛋白(ABP)和膜脂,尤其是磷酸肌醇PI(4,5)P2和PI(3,4,5)P3参与了这种重组的调节。据报道,至少有15种ABP与磷酸肌醇(PIP)相互作用或受其调节,而PIP的合成受细胞外信号调节。最近的研究发现了几条在趋化细胞中相互串扰的平行细胞内信号通路。在这里,我们综述了ABP和磷酸肌醇在趋化性和细胞迁移中的作用。
本文是关于细胞骨架、细胞外基质、细胞迁移、伤口愈合及相关主题的主题部分的一部分。要查看本节中的其他文章,请访问http://dx.doi.org/10.1111/bph.2014.171.issue-24 。