EA2992 Dysfunction of Vascular Interfaces Laboratory, Montpellier I University, Montpellier - Nimes Faculty of Medicine, Nimes, France.
Obesity (Silver Spring). 2012 Jan;20(1):134-40. doi: 10.1038/oby.2011.270. Epub 2011 Aug 25.
The aim of this study was to evaluate the impact of a low-intensity training program on subclinical cardiac dysfunction and on dyssynchrony in moderately obese middle aged men. Ten obese and 14 age-matched normal-weight men (BMI: 33.6 ± 1.0 and 24.2 ± 0.5 kg/m(2)) were included. Obese men participated in an 8-week low-intensity training program without concomitant diet. Cardiac function and myocardial synchrony were assessed by echocardiography with tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE). At baseline, obese men showed diastolic dysfunction on standard echocardiography, lower strain values (systolic strain: 15.9 ± 0.9 vs. 18.8 ± 0.3%, diastolic strain rate: 0.81 ± 0.09 vs. 1.05 ± 0.06 s(-1)), and significant intraventricular dyssynchrony (systolic: 13.3 ± 2.1 vs. 5.4 ± 2.1 ms, diastolic: 17.4 ± 3.2 vs. 9.1 ± 2.1 ms) (P < 0.05 vs. controls for all variables). Training improved aerobic fitness, decreased systolic blood pressure and heart rate, and reduced fat mass without weight loss. Diastolic function, strain values (systolic strain: 17.4 ± 0.9%, diastolic strain rate: 0.96 ± 0.12 s(-1)) and intraventricular dyssynchrony (systolic: 3.3 ± 1.7 ms, diastolic: 5.5 ± 3.4 ms) improved significantly after training (P < 0.05 vs. baseline values for all variables), reaching levels similar to those of normal-weight men. In conclusion, in obese men, a short and easy-to-perform low intensity training program restored diastolic function and cardiac synchrony and improved body composition without weight loss.
这项研究的目的是评估低强度训练计划对亚临床心脏功能障碍和中度肥胖中年男性心脏不同步的影响。纳入 10 名肥胖和 14 名年龄匹配的正常体重男性（BMI：33.6 ± 1.0 和 24.2 ± 0.5 kg/m2）。肥胖男性参加了 8 周的低强度训练计划，但不进行饮食控制。通过组织多普勒成像（TDI）和斑点追踪超声心动图（STE）评估心脏功能和心肌同步性。在基线时，肥胖男性的标准超声心动图显示舒张功能障碍，应变值较低（收缩期应变：15.9 ± 0.9%对 18.8 ± 0.3%，舒张期应变率：0.81 ± 0.09 对 1.05 ± 0.06 s-1），并且存在明显的室内不同步（收缩期：13.3 ± 2.1 对 5.4 ± 2.1 ms，舒张期：17.4 ± 3.2 对 9.1 ± 2.1 ms）（所有变量 P < 0.05 与对照组相比）。训练改善了有氧适能，降低了收缩压和心率，减少了脂肪量，而体重没有减轻。舒张功能、应变值（收缩期应变：17.4 ± 0.9%，舒张期应变率：0.96 ± 0.12 s-1）和室内不同步（收缩期：3.3 ± 1.7 ms，舒张期：5.5 ± 3.4 ms）在训练后显著改善（所有变量 P < 0.05 与基线值相比），达到与正常体重男性相似的水平。总之，在肥胖男性中，短期、易于执行的低强度训练计划可在不减轻体重的情况下恢复舒张功能和心脏同步性，并改善身体成分。
