[过氧化物酶体增殖物激活受体：结构、作用机制与调控。注释I]

[PPARs: structure, mechanisms of action and control. Note I].

作者信息

Filip-Ciubotaru Florina, Foia Liliana, Manciuc Carmen, Grigore Cecilia

机构信息

Universitatea de Medicină Si Farmacie Gr. T. Popa Iaşi Facultatea de Medicină, Disciplina de Medicina de Familie.

出版信息

Rev Med Chir Soc Med Nat Iasi. 2011 Apr-Jun;115(2):477-84.

PMID:21870744

Abstract

PPARs (peroxisome proliferator activated receptors) are proteine receptors that act as transcription factors activated by ligands. There are three known isoforms of PPARs (alpha, beta/delta, gamma) with similar modulated structure, consisting of distinct regions with specific functions. PPARs activate transcription of their target genes by forming cytoplasmatic heterodimers (PPARs:RXR) with his partner RXR (retinoid X receptor), and once translocated into the nucleus bind to specific DNA sequence called PPRE (peroxisome proliferator response elements) and modulate the expression of genes. Each PPAR is differently expressed in various tissues. Modulatory function of PPARs is induced by natural or synthetic ligand binding. Additional activator proteins are recruited to form a complex that coordinates and regulates the expression of many genes. Moreover, nuclear receptors' activity is also regulated by posttranslational changes.

摘要

过氧化物酶体增殖物激活受体（PPARs）是作为由配体激活的转录因子的蛋白质受体。已知有三种PPARs亚型（α、β/δ、γ），其结构具有相似的调控性，由具有特定功能的不同区域组成。PPARs通过与伴侣视黄醇X受体（RXR）形成细胞质异二聚体（PPARs:RXR）来激活其靶基因的转录，一旦转移到细胞核中，就会与称为过氧化物酶体增殖物反应元件（PPRE）的特定DNA序列结合，并调节基因表达。每种PPAR在各种组织中的表达各不相同。PPARs的调节功能是由天然或合成配体结合诱导的。其他激活蛋白被招募形成一个复合物，该复合物协调并调节许多基因的表达。此外，核受体的活性也受到翻译后变化的调节。