Gnezdilova A V, Lebedeva M A, Gan'shina T S, Mirzoian R S
Eksp Klin Farmakol. 2011;74(6):20-3.
The effect of mexidol on cerebral blood flow under conditions of experimental myocardial infarction and combined disturbances of cerebral and coronary perfusion in comparison with intact and false-operated rats and rats after global transient ischemia of brain was studied. It is established that mexidol (200 mg/kg) more prominently enhances the blood flow in the parietal region of brain cortex of rats with combined ischemia of brain and heart as compared to intact rats and rats after experimental myocardial infarction. Under conditions of combined pathology, mexidol produces the same cerebrovascular effect as that in animals with cerebral ischemia.
研究了美西多福在实验性心肌梗死及脑和冠状动脉灌注联合障碍条件下对脑血流的影响，并与完整大鼠、假手术大鼠以及脑全脑短暂缺血后的大鼠进行了比较。结果表明，与完整大鼠和实验性心肌梗死后的大鼠相比，美西多福（200mg/kg）能更显著地增强脑和心脏联合缺血大鼠大脑皮质顶叶区域的血流。在联合病理状态下，美西多福产生的脑血管效应与脑缺血动物相同。
