Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106-7078, USA.
Chem Res Toxicol. 2011 Nov 21;24(11):1791-802. doi: 10.1021/tx200207z. Epub 2011 Sep 30.
Basic research, exploring the hypothesis that γ-hydroxyalkenal phospholipids are generated in vivo through oxidative cleavage of polyunsaturated phospholipids, is delivering a bonanza of molecular mechanistic insights into cardiovascular disease. Rather than targeting a specific pathology, these studies were predicated on the presumption that a fundamental understanding of lipid oxidation is likely to provide critical insights into disease processes. This investigational approach, from the chemistry of biomolecules to disease phenotype, that complements the more common opposite paradigm, is proving remarkably productive.
基础研究探索了假说，即γ-羟烯醛磷脂在体内通过多不饱和磷脂的氧化裂解产生，为心血管疾病的分子机制提供了丰富的见解。这些研究不是针对特定的病理学，而是基于这样的假设，即对脂质氧化的基本理解可能为疾病过程提供关键的见解。从生物分子化学到疾病表型的这种研究方法补充了更为常见的相反模式，事实证明是非常有成效的。
