Ross Matthew K, Matthews Anberitha T, Mangum Lee C
Center for Environmental Health Sciences, Department of Basic Sciences, College of Veterinary Medicine, Mississippi State University, Mississippi State, MS 39762, USA;
Toxics. 2014;2(1):17-34. doi: 10.3390/toxics2010017.
Chemical atherogenesis is an emerging field that describes how environmental pollutants and endogenous toxins perturb critical pathways that regulate lipid metabolism and inflammation, thus injuring cells found within the vessel wall. Despite growing awareness of the role of environmental pollutants in the development of cardiovascular disease, the field of chemical atherogenesis can broadly include both exogenous and endogenous poisons and the study of molecular, biochemical, and cellular pathways that become dysregulated during atherosclerosis. This integrated approach is logical because exogenous and endogenous toxins often share the same mechanism of toxicity. Chemical atherogenesis is a truly integrative discipline because it incorporates concepts from several different fields, including biochemistry, chemical biology, pharmacology, and toxicology. This review will provide an overview of this emerging research area, focusing on cellular and animal models of disease.
化学致动脉粥样硬化是一个新兴领域，它描述了环境污染物和内源性毒素如何扰乱调节脂质代谢和炎症的关键途径，从而损伤血管壁中的细胞。尽管人们越来越意识到环境污染物在心血管疾病发展中的作用，但化学致动脉粥样硬化领域广泛涵盖外源性和内源性毒物，以及对动脉粥样硬化过程中失调的分子、生化和细胞途径的研究。这种综合方法是合理的，因为外源性和内源性毒素通常具有相同的毒性机制。化学致动脉粥样硬化是一门真正的综合学科，因为它融合了生物化学、化学生物学、药理学和毒理学等几个不同领域的概念。本综述将概述这一新兴研究领域，重点关注疾病的细胞和动物模型。
