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高龄患者行心脏手术可获得长期生存和生活质量。

Long-term survival and quality of life justify cardiac surgery in the very elderly patient.

机构信息

Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

出版信息

Ann Thorac Surg. 2011 Sep;92(3):851-7. doi: 10.1016/j.athoracsur.2011.04.083.

Abstract

BACKGROUND

Elderly patients are often discouraged from undergoing cardiac surgery procedures owing to the perception of high mortality and poor functional outcomes. This study evaluates long-term survival and quality of life after cardiac surgery in octogenarian and nonagenarian patients.

METHODS

We identified a 459 patient cohort greater than 80 years of age who underwent elective cardiac surgery at our institution from 1994 to 1999. Survival was assessed with Kaplan-Meier analysis and compared with an age-matched and sex-matched population cohort. Among survivors, quality of life was assessed 8 years postoperatively using the Medical Outcomes Study Short Form 12 Health Survey, version 2. Risk factors for mortality were identified with Cox regression.

RESULTS

Operative mortality was 4.1%. Actuarial postoperative 5-year and 10-year survival was 53% and 27%, respectively. When compared with age- and sex-matched general population data, relative survival (excluding operative deaths) was 90.4% at 5 years and 78.7% at 10 years. Risk factors for late mortality included age greater than 85, male sex, low body mass index, renal failure, and postoperative respiratory failure. Survivors' median quality of life mental health score was higher (55.2 versus 48.9; p<0.05) and physical health score was equivalent (39.3 versus 39.8; p=0.66) to the general elderly population.

CONCLUSIONS

Cardiac surgery in the very elderly patient can be performed with low operative mortality, excellent long-term survival, and postoperative quality of life exceeding that of the general elderly population.

摘要

背景

由于高龄患者死亡率高和功能预后差的观念,老年患者常被劝阻进行心脏手术。本研究评估了 80 岁及以上高龄患者行心脏手术后的长期生存和生活质量。

方法

我们在机构中确定了 1994 年至 1999 年间接受择期心脏手术的 459 例 80 岁以上患者队列。通过 Kaplan-Meier 分析评估生存情况,并与年龄和性别匹配的人群队列进行比较。在幸存者中,术后 8 年使用医疗结局研究短表 12 健康调查(第 2 版)评估生活质量。使用 Cox 回归识别死亡率的危险因素。

结果

手术死亡率为 4.1%。术后 5 年和 10 年的生存率分别为 53%和 27%。与年龄和性别匹配的一般人群数据相比,5 年时相对生存率(不包括手术死亡)为 90.4%,10 年时为 78.7%。晚期死亡的危险因素包括年龄大于 85 岁、男性、低体重指数、肾衰竭和术后呼吸衰竭。幸存者的中位心理健康评分更高(55.2 比 48.9;p<0.05),身体健康评分与一般老年人群相当(39.3 比 39.8;p=0.66)。

结论

高龄患者的心脏手术可以在低手术死亡率的情况下进行,具有极好的长期生存和术后生活质量,超过了一般老年人群。

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