Division of Cardiac Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Mass. 02115, USA.
J Thorac Cardiovasc Surg. 2010 Jul;140(1):103-9, 109.e1. doi: 10.1016/j.jtcvs.2009.10.001. Epub 2009 Dec 14.
Elderly patients might be denied nonelective cardiac surgery because of the perception of poor outcomes and an unacceptable quality of life. In this study we evaluate long-term survival and quality of life in these patients.
From 1994 to 1999, 262 consecutive patients older than 80 years underwent urgent (n = 223) or emergent (n = 39) cardiac surgery. Of these patients, 160 (61%) underwent coronary artery bypass grafting, 64 (24%) underwent coronary artery bypass grafting plus valve surgery, 17 (7%) underwent valve surgery, and 21 (8%) underwent aortic surgery. Kaplan-Meier survival analysis and quality-of-life assessment were performed, and result were compared with age-adjusted population data. Risk factors for mortality were determined by using Cox regression. The utility of Society of Thoracic Surgeons and EuroSCORE risk scoring were assessed by using area under receiver operating curves.
Early mortality was 11% (n = 29) overall, 7% (n = 16) in urgent cases, and 33% (n = 13) in emergent cases. Five-year survival was 50% (n = 132) overall, 53% (n = 105) in urgent cases, and 36% (n = 18) in emergent cases. There was no difference in 10-year survival between patients undergoing urgent surgical intervention and age-adjusted population data. Among survivors, quality-of-life measures were equivalent to those of the general elderly population. Risk factors for early mortality were age, emergent procedure, aortic procedure, bypass time, and postoperative complication (renal failure, myocardial infarction, cerebrovascular accident, pneumonia, and reoperation for bleeding). Risk factors for late mortality were peripheral vascular disease, emergent procedure, bypass time, and new renal failure. The EuroSCORE and Society of Thoracic Surgeons risk scores were equivalent but only moderately predictive of mortality.
Long-term survival and quality of life after nonelective cardiac surgery can equal that of the general elderly population. Age alone should not disqualify a patient for urgent or emergent cardiac surgery.
由于对不良预后和不可接受的生活质量的认知,老年患者可能被拒绝接受非选择性心脏手术。本研究旨在评估这些患者的长期生存和生活质量。
1994 年至 1999 年间,262 例年龄大于 80 岁的连续患者接受了紧急(n=223)或紧急(n=39)心脏手术。这些患者中,160 例(61%)接受了冠状动脉旁路移植术,64 例(24%)接受了冠状动脉旁路移植术加瓣膜手术,17 例(7%)接受了瓣膜手术,21 例(8%)接受了主动脉手术。进行了 Kaplan-Meier 生存分析和生活质量评估,并与年龄调整后的人群数据进行了比较。使用 Cox 回归确定死亡率的危险因素。通过接受者操作特征曲线下面积评估了胸外科医生协会和 EuroSCORE 风险评分的效用。
总体而言,早期死亡率为 11%(n=29),紧急病例为 7%(n=16),紧急病例为 33%(n=13)。5 年总生存率为 50%(n=132),紧急手术为 53%(n=105),紧急手术为 36%(n=18)。接受紧急手术干预的患者与年龄调整后的人群数据相比,10 年生存率无差异。在幸存者中,生活质量测量结果与一般老年人群相当。早期死亡率的危险因素包括年龄、紧急手术、主动脉手术、旁路时间和术后并发症(肾衰竭、心肌梗死、脑血管意外、肺炎和出血再手术)。晚期死亡率的危险因素包括外周血管疾病、紧急手术、旁路时间和新的肾衰竭。EuroSCORE 和胸外科医生协会风险评分是等效的,但仅对死亡率有中等预测能力。
非选择性心脏手术后的长期生存和生活质量可与一般老年人群相当。仅年龄不应使患者丧失接受紧急或紧急心脏手术的资格。