Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India.
Colloids Surf B Biointerfaces. 2011 Dec 1;88(2):568-73. doi: 10.1016/j.colsurfb.2011.07.034. Epub 2011 Jul 23.
In this paper we report clouding phenomenon occurring in an amphiphilic phenothiazine drug promethazine hydrochloride (PMT) in presence of surfactants. Cationic and nonionic surfactants increase the CP of 75 mM PMT solutions (prepared in 10 mM sodium phosphate buffer). These surfactants form mixed micelles with PMT. Anionic surfactants also form mixed micelles with the drug but the CP behavior is different by showing a peaked behavior. At low concentrations, anionic surfactants hinder micelle formation by forming ion-pairs whereas the usual CP decreasing effect at higher concentrations is due to mixed micellization. The CP behavior of 75 mM PMT+50 mM TBAB+surfactant systems is also explored which is found similar to PMT+surfactant systems with the difference only in magnitude of the clouding temperature.
在本文中，我们报告了在表面活性剂存在下，一种两亲性吩噻嗪药物盐酸普罗米嗪（PMT）中出现的浑浊现象。阳离子和非离子表面活性剂增加了 75mM PMT 溶液（在 10mM 磷酸钠缓冲液中制备）的 CP。这些表面活性剂与 PMT 形成混合胶束。阴离子表面活性剂也与药物形成混合胶束，但 CP 行为不同，表现出峰形行为。在低浓度下，阴离子表面活性剂通过形成离子对来阻碍胶束形成，而在较高浓度下通常由于混合胶束化而导致 CP 降低效应。还研究了 75mM PMT+50mM TBAB+表面活性剂体系的 CP 行为，发现其与 PMT+表面活性剂体系相似，仅在浊点温度的大小上有所不同。
