Department of Chemistry, Aligarh Muslim University, Aligarh 202 002, India.
J Colloid Interface Sci. 2011 Feb 15;354(2):700-8. doi: 10.1016/j.jcis.2010.11.005. Epub 2010 Nov 11.
Micellization of an amphiphilic phenothiazine drug promethazine hydrochloride (PMT) in presence of conventional (CTAB and TTAB) as well as gemini (16-s-16 and 14-s-14, s=4-6) cationic surfactants has been studied conductometrically at different temperatures. Critical micelle concentration values (cmc and cmc(id)) indicate mixed micelle formation among the two components. Micellar mole fractions of surfactants (X(1), X(1)(M) and X(1)(id)) show greater contribution of surfactants. Interaction parameter, β, suggests attractive interactions in the mixed systems. The thermodynamic parameters suggest dehydration of hydrophobic part of the drug at higher temperatures.
在不同温度下，通过电导法研究了两亲性吩噻嗪药物盐酸普罗米嗪（PMT）在常规（CTAB 和 TTAB）以及双子（16-s-16 和 14-s-14，s=4-6）阳离子表面活性剂存在下的胶束化。临界胶束浓度值（cmc 和 cmc(id))表明两种组分之间形成了混合胶束。表面活性剂的胶束摩尔分数（X(1), X(1)(M) 和 X(1)(id))表明表面活性剂的贡献更大。相互作用参数β表明混合体系中存在吸引力相互作用。热力学参数表明在较高温度下药物疏水区发生了脱水。
