Université Paris Descartes, Département de Cardiologie, Groupe Hospitalier Cochin-Broca-Hôtel Dieu, Assistance Publique des Hôpitaux de Paris, 27 rue du Fbg St-Jacques, 75679 Paris Cedex 14, France.
Clin Biochem. 2011 Nov;44(16):1315-9. doi: 10.1016/j.clinbiochem.2011.08.906. Epub 2011 Aug 17.
Atrial fibrillation (AF) is a common arrhythmia; its most prevalent and devastating complication is stroke. A delay of AF onset >48 h is believed to be clinically significant. Mid-regional pro A-type natriuretic peptide (MR-proANP) could be of interest in the identification of the time from onset of AF to presentation.
We measured MR-proANP plasma concentration at presentation in consecutive patients in whom onset of AF was determined, without evidence of concomitant acute heart failure.
Forty-seven patients were included. Patients with an AF onset <48 h (n=19) had decreased MR-proANP concentrations versus patients with onset >48 h (144.0 [129.2-213.7] versus 321.7 [236.4-425.6] pmol/L, p<0.001); MR-proANP was the only independent variable associated with AF <48 h according to multivariate analysis. Area under the ROC curve for identify AF onset <48 h was 0.878 [95%CI 0.778-0.978].
MR-proANP concentration may reliably identify the time from onset of AF to presentation.
心房颤动（AF）是一种常见的心律失常；其最常见且最具破坏性的并发症是中风。通常认为，AF 发作后 >48 小时具有临床意义。中区域 pro A 型利钠肽（MR-proANP）可能有助于确定从 AF 发作到就诊的时间。
我们在连续就诊的患者中测量了 AF 发作时的 MR-proANP 血浆浓度，这些患者没有急性心力衰竭的证据。
共纳入 47 例患者。AF 发作 <48 小时的患者（n=19）MR-proANP 浓度低于发作 >48 小时的患者（144.0[129.2-213.7]比 321.7[236.4-425.6]pmol/L，p<0.001）；多变量分析显示，MR-proANP 是唯一与 AF 发作 <48 小时相关的独立变量。用于识别 AF 发作 <48 小时的 ROC 曲线下面积为 0.878[95%CI 0.778-0.978]。
MR-proANP 浓度可以可靠地识别从 AF 发作到就诊的时间。
