Department of Obstetrics and Gynecology, Meram Medical School, Selçuk University, Konya, Turkey.
Int J Gynaecol Obstet. 2011 Nov;115(2):140-3. doi: 10.1016/j.ijgo.2011.05.025. Epub 2011 Aug 26.
To evaluate the clinical features, pregnancy outcome, and treatment of patients with ovarian cancer diagnosed during pregnancy.
The present study was a retrospective review of 11 cases of ovarian cancer detected during pregnancy. The women were treated and followed up at Selçuk University, Meram Faculty of Medicine, Konya, Turkey, during 2006-2010.
Approximately half the patients were asymptomatic (5 [45.5%]) and diagnosed during cesarean delivery (6 [54.5%]). The histopathologic tumor categories comprised malignant epithelial ovarian tumor (4 [36.4%]), borderline tumor (4 [36.4%]), malignant germ cell tumor (2 [18.2%]), and sex cord stromal tumor (1 [9.1%]). Nine (81.8%) tumors were classified as stage I. Conservative surgery was performed in 10 (90.9%) patients. A patient with stage IIIC serous papillary adenocarcinoma underwent hysterectomy with bilateral salpingo-oophorectomy. A patient with dysgerminoma in stage IV died on follow-up. Three infants were born premature; they were followed up in the neonatal intensive care unit with satisfactory outcomes.
Early diagnosis and appropriate treatment are crucial for patients with ovarian cancer diagnosed during pregnancy. Tumor staging is possible during pregnancy, but the appropriateness of surgery needs to be considered carefully. Ideally, the treatment strategy should be discussed and structured on an individual basis.
评估妊娠期诊断为卵巢癌患者的临床特征、妊娠结局和治疗方法。
本研究回顾性分析了 2006 年至 2010 年期间在土耳其科尼亚塞尔丘克大学梅拉姆医学院接受治疗和随访的 11 例妊娠期卵巢癌患者。
约一半的患者无症状（5 [45.5%]），且在剖宫产时诊断（6 [54.5%]）。组织病理学肿瘤类别包括恶性上皮性卵巢肿瘤（4 [36.4%]）、交界性肿瘤（4 [36.4%]）、恶性生殖细胞肿瘤（2 [18.2%]）和性索-间质肿瘤（1 [9.1%]）。9 例（81.8%）肿瘤分期为 I 期。10 例（90.9%）患者行保守性手术。1 例 IIIC 期浆液性乳头状腺癌患者行子宫切除术加双侧附件切除术。1 例 IV 期胚胎瘤患者死亡。3 例婴儿早产，在新生儿重症监护病房接受随访，结局良好。
对于妊娠期诊断为卵巢癌的患者，早期诊断和适当的治疗至关重要。妊娠期可进行肿瘤分期，但需要仔细考虑手术的适宜性。理想情况下，应根据个体情况讨论和制定治疗策略。
