Luh Lany Christina Prajawati Ni, Mahendra I Nyoman Bayu, Suwiyoga Ketut, Budiana Ing, Mayura Igp Mayun, Wiradnyana Aag Putra, Putra I Wayan Artana, Negara I Ketut Surya, Ariawati Ketut, Dewi Iga Sri Mahendra, Susraini Aaa Ngurah, Sriwidyani Ni Putu, Wirawan Wahyudi, Vikananda Ida Ayu
Obstetrics and Gynaecologic Registrar, Obstetrics and Gynecologic Department, Bali, Indonesia.
Oncology-Gynecology Division, Bali, Indonesia.
Open Access Maced J Med Sci. 2019 Apr 3;7(7):1174-1179. doi: 10.3889/oamjms.2019.251. eCollection 2019 Apr 15.
Malignant Ovarian Germ Cell Tumors (MOGCT) most commonly occur in young women in the reproductive age group. Timely antenatal diagnosis and treatment of the tumour to enhance maternal and perinatal outcomes are the main challenges confronting the obstetrician and the gyne-oncologist.
Here we present three cases of pregnancy complicated with MOGCTs. The first case (immature teratoma) was complicated by maternal psychological symptoms consistent with stress and histopathological examination confirmed the diagnosis of premature ovarian failure (POF). The second case (dysgerminoma) preterm labour occurred as an obstetric complication, but the baby was born in good condition without IUGR. The third case (yolk sac tumour) treated with docetaxel (brexel)-carboplatin chemotherapy administration there was no maternal or fetal complication. At the end of the pregnancy and delivery, complete surgical staging and cytoreduction were performed, and no metastases were found.
Optimal management strategies centre on a multi-disciplinary comprehensive team approach is critical resulting in better outcomes for the mother and the baby by avoiding complications.
恶性卵巢生殖细胞肿瘤（MOGCT）最常发生于育龄期年轻女性。及时进行产前肿瘤诊断和治疗以改善孕产妇和围产期结局，是产科医生和妇科肿瘤学家面临的主要挑战。
我们在此呈现三例妊娠合并MOGCT的病例。第一例（未成熟畸胎瘤）伴有与压力相符的母体心理症状，组织病理学检查确诊为卵巢早衰（POF）。第二例（无性细胞瘤）早产作为产科并发症发生，但婴儿出生时状况良好，无宫内生长受限。第三例（卵黄囊瘤）采用多西他赛（多西紫杉醇）-卡铂化疗，未出现母体或胎儿并发症。妊娠和分娩结束时，进行了完整的手术分期和肿瘤细胞减灭术，未发现转移灶。
以多学科综合团队方法为核心的最佳管理策略至关重要，通过避免并发症可为母亲和婴儿带来更好的结局。
