Maternité Port-Royal, Groupe Hospitalier Cochin Broca Hôtel-Dieu, Assistance Publique-Hôpitaux de Paris, Paris, France.
Int J Gynaecol Obstet. 2011 Nov;115(2):153-6. doi: 10.1016/j.ijgo.2011.06.012. Epub 2011 Aug 26.
To determine whether ethnic origin is related to the clinical and biologic expression of pre-eclampsia.
In a secondary analysis of information collected in the ECLAXIR study in France between May 2003 and October 2006, the data from 284 white European, 84 Maghrebian and 158 African women were evaluated in a case-control study of the genetic and endothelial determinants of pre-eclampsia.
African origin was a risk factor for pre-eclampsia before 28 weeks of gestation. Symptoms related to hypertension, such as neurologic signs and changes in biologic parameters (e.g. hemolysis elevated liver enzymes, low platelet count [HELLP] syndrome), occurred more frequently among white European women. After logistic regression, gestational age at delivery was lower for African women than for white European women (33.4 weeks versus 34.4 weeks of gestation, P=0.04).
The results suggest that ethnic origin may have a role in the expression of pre-eclampsia, and should therefore be taken into account in prenatal surveillance. Further research on the genetic factors involved in endothelial dysfunction is warranted.
确定种族是否与子痫前期的临床和生物学表现有关。
在 2003 年 5 月至 2006 年 10 月期间在法国进行的 ECLAXIR 研究的信息的二次分析中，对 284 名白种欧洲人、84 名马格里布人和 158 名非洲妇女的数据进行了病例对照研究，评估了子痫前期的遗传和内皮决定因素。
非洲血统是 28 周前子痫前期的危险因素。白种欧洲妇女更容易出现与高血压相关的症状，如神经系统体征和生物学参数变化（如溶血升高肝酶、血小板计数低[HELLP]综合征）。经过逻辑回归，非洲裔妇女的分娩孕周比白种欧洲妇女低（33.4 周与 34.4 周妊娠，P=0.04）。
结果表明，种族可能在子痫前期的表现中起作用，因此在产前监测中应考虑到这一点。有必要进一步研究内皮功能障碍相关的遗传因素。
