用于检测班氏丝虫病的体外释放的班氏吴策线虫第三期幼虫抗原的评估
Evaluation of in vitro released Wuchereria bancrofti third stage larval antigens for detection of Bancroftian filariasis.
作者信息
Carvalho P A, Rajasekariah G R, Desphande L, Parab P B, Rao U R, Subrahmanyam D
机构信息
Research Centre, Hindustan Ciba-Geigy Ltd., Goregaon East, Bombay, India.
出版信息
Trop Med Parasitol. 1990 Mar;41(1):71-2.
Three types of in vitro released excretory, secretory and metabolic antigens of Wuchereria bancrofti third larval stage (L3ESM) are evaluated in ELISA test to detect infected individuals in the endemic area. A total of 104 reference sera are used to predict the sensitivity of these antigens. None of L3 ESM antigens, although homologous in nature, did not identify correctly the categorised reference sera. This study clearly indicated a need for defined antigens to detect W. bancrofti infection early in the endemic residents.
对班氏吴策线虫第三期幼虫的三种体外释放的排泄、分泌和代谢抗原（L3ESM）进行酶联免疫吸附测定（ELISA）试验评估，以检测流行地区的感染个体。总共使用104份参考血清来预测这些抗原的敏感性。尽管L3 ESM抗原本质上具有同源性，但没有一种抗原能正确识别分类后的参考血清。这项研究清楚地表明，需要有明确的抗原以便在流行地区居民中早期检测班氏吴策线虫感染。
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