基于代谢的治疗中的神经保护。
Neuroprotection in metabolism-based therapy.
机构信息
Johns Hopkins University, Neurology, 600 N. Wolfe St., Meyer 2-147, Baltimore, MD 21287, USA.
出版信息
Epilepsy Res. 2012 Jul;100(3):286-94. doi: 10.1016/j.eplepsyres.2011.04.016. Epub 2011 Aug 26.
Abstract
Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating the use of different forms of metabolism-based therapy in human trials of Alzheimer disease and Parkinson disease are discussed. Animal and in vitro studies have shed light on metabolism-based therapy's mechanisms in these diseases, as well as ALS, aging, ischemia, trauma and mitochondrial cytopathies. Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy).
摘要
基于代谢的治疗方法已成功用于治疗癫痫，但研究其在其他神经退行性疾病中的应用正在增加。本文讨论了在阿尔茨海默病和帕金森病的人类临床试验中使用不同形式的基于代谢的治疗方法的数据。动物和体外研究揭示了基于代谢的治疗方法在这些疾病以及肌萎缩侧索硬化症、衰老、缺血、创伤和线粒体细胞病变中的作用机制。通过考虑基于代谢的治疗方法在细胞功能障碍和死亡（特别是细胞凋亡、兴奋毒性和自噬）中的作用，可能会获得更多的见解。
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