Department of Neurology, Affiliated Hospital of Beihua University, 12 Jiefang Road, Jilin 132011, China.
J Clin Neurosci. 2011 Nov;18(11):1534-7. doi: 10.1016/j.jocn.2010.12.032. Epub 2011 Aug 26.
Members of the NDRG (N-Myc downstream-regulated) gene family have been shown to play a variety of roles in human malignancies. In the present study, we examined the expression of NDRG2 protein in glioma samples of WHO grades I-IV. We also investigated the association between NDRG2 expression and survival. Immunohistochemical analysis was used to measure NDRG2 protein expression in 316 specimens of human glioma and 41 normal control tissues. Survival analysis was performed using the Kaplan-Meier method and Cox's proportional hazards model. We found that NDRG2 expression was reduced in glioma relative to normal tissue, and that NDRG2 expression decreased with increasing glioma grade. Kaplan-Meier analysis showed that patients without NDRG2 expression had a lower survival rate than other patients. Multivariate analysis showed that NDRG2 expression was an independent prognostic factor for overall survival of patients with glioma. The present study provides the first evidence that NDRG2 expression is decreased in gliomas, indicating that NDRG2 may play an inhibitory role during the development of gliomas. NDRG2 expression may also be a significant and independent prognostic indicator for glioma.
NDRG（N-Myc 下游调节）基因家族的成员已被证明在人类恶性肿瘤中发挥多种作用。在本研究中，我们检查了 NDRG2 蛋白在 WHO 分级 I-IV 的脑胶质瘤样本中的表达。我们还研究了 NDRG2 表达与生存之间的关联。免疫组织化学分析用于测量 316 个人类脑胶质瘤标本和 41 个正常对照组织中 NDRG2 蛋白的表达。使用 Kaplan-Meier 方法和 Cox 比例风险模型进行生存分析。我们发现 NDRG2 表达在胶质瘤中相对于正常组织减少，并且 NDRG2 表达随着胶质瘤分级的增加而降低。Kaplan-Meier 分析表明，没有 NDRG2 表达的患者的生存率低于其他患者。多变量分析表明，NDRG2 表达是脑胶质瘤患者总生存的独立预后因素。本研究首次提供证据表明 NDRG2 表达在脑胶质瘤中减少，表明 NDRG2 可能在脑胶质瘤的发展过程中发挥抑制作用。NDRG2 表达也可能是脑胶质瘤的一个重要且独立的预后指标。
