Hackett Catherine H, Fortier Lisa A
Department of Clinical Sciences, Box 32, Veterinary Medical Center, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA.
Vet Clin North Am Equine Pract. 2011 Aug;27(2):233-42. doi: 10.1016/j.cveq.2011.04.003. Epub 2011 Jun 16.
The field of regenerative medicine research is rapidly expanding. One area of interest to equine researchers is the possibility of isolating or generating pluripotent cells, capable of producing differentiated cell types derived from all 3 primary germ layers. Reports of equine embryonic stem-like (ES) cell isolation can be found in the literature. Other groups are working to produce equine-induced pluripotent stem (iPS) cells. This article summarizes the essential features needed to characterize a cell type as pluripotent, specific challenges in using the horse as a model organism for pluripotent cell generation, and current and upcoming clinical trials using ES/iPS cells.
再生医学研究领域正在迅速扩展。马研究人员感兴趣的一个领域是分离或生成多能细胞的可能性，这些细胞能够产生源自所有三个原始胚层的分化细胞类型。文献中可以找到马胚胎干细胞样（ES）细胞分离的报告。其他团队正在致力于产生马诱导多能干细胞（iPS）。本文总结了将一种细胞类型表征为多能细胞所需的基本特征、将马用作多能细胞生成模型生物时面临的特定挑战，以及目前和即将开展的使用ES/iPS细胞的临床试验。
