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循证医学与干细胞疗法:我们如何知晓此类技术是安全且有效的?

Evidence-based medicine and stem cell therapy: how do we know such technologies are safe and efficacious?

作者信息

Clegg Peter D, Pinchbeck Gina L

机构信息

Department of Musculoskeletal Biology, University of Liverpool, Leahurst Campus, Chester High Road, Neston, Cheshire, CH64 7TE, UK.

出版信息

Vet Clin North Am Equine Pract. 2011 Aug;27(2):373-82. doi: 10.1016/j.cveq.2011.04.002. Epub 2011 Jun 12.

DOI:10.1016/j.cveq.2011.04.002
PMID:21872765
Abstract

Evidence-based medicine (EBM) refers to the conscientious, explicit, and judicious use of current best evidence from research for the care of an individual patient. Central to the adoption of EBM is both producing and identifying the best possible evidence for a particular intervention or therapy. This article identifies and reviews the approaches to producing and identifying the best possible evidence that is necessary for the full acceptance of stem cell therapies in the horse and reviews the approaches that will allow future clinical studies in stem cell therapies to provide the best evidence for determining efficacy.

摘要

循证医学(EBM)是指在照顾个体患者时,认真、明确且审慎地运用当前研究得出的最佳证据。采用循证医学的核心在于为特定干预措施或治疗方法生成并确定尽可能最佳的证据。本文确定并综述了生成和确定马匹完全接受干细胞疗法所需的尽可能最佳证据的方法,并综述了能使未来干细胞疗法临床研究为确定疗效提供最佳证据的方法。

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