Department of Neurology, Oregon Health and Science University, Portland, OR, USA.
Arch Phys Med Rehabil. 2011 Oct;92(10):1594-601. doi: 10.1016/j.apmr.2011.05.017. Epub 2011 Aug 27.
To evaluate reported fatigue levels and gait deficits in patients with multiple sclerosis (MS) to determine the relationships that may exist between fatigue in patients with MS and alterations in gait mechanics.
Cross-sectional.
Biomechanics laboratory.
Subjects with MS (n=32) and age- and sex-matched controls (n=30).
None.
Fatigue Severity Scale (FSS), Modified Fatigue Index Scale (MFIS), and 36-Item Short Form Health Survey (SF-36) to assess fatigue and general health. Biomechanical gait analysis was performed to measure peak joint torques and powers in the sagittal plane at the ankle, knee, and hip. Correlations were performed between fatigue measures and degree of deficit within each patient with MS for each joint torque and power measure.
FSS score significantly correlated with deficits in ankle power generation at late stance and walking velocity. MFIS score significantly correlated with deficits in peak knee extensor torque and knee power absorption at early stance. SF-36 subscale scores correlated with several joint torque and power variables.
Subjective fatigue rating scale scores alone should not be used as an indicator of motor disability or disease progression as it affects walking performance of patients with MS.
评估多发性硬化症（MS）患者报告的疲劳水平和步态缺陷，以确定 MS 患者的疲劳与步态力学改变之间可能存在的关系。
横断面研究。
生物力学实验室。
MS 患者（n=32）和年龄、性别匹配的对照组（n=30）。
无。
疲劳严重程度量表（FSS）、改良疲劳指数量表（MFIS）和 36 项简短健康调查问卷（SF-36）评估疲劳和一般健康状况。进行生物力学步态分析，以测量踝关节、膝关节和髋关节矢状面的峰值关节扭矩和功率。对每个关节扭矩和功率测量值，对每个 MS 患者的疲劳测量值与缺陷程度之间进行相关性分析。
FSS 评分与后期站立和行走速度时的踝关节功率产生缺陷显著相关。MFIS 评分与早期站立时的膝关节伸肌扭矩和膝关节功率吸收缺陷显著相关。SF-36 子量表评分与几个关节扭矩和功率变量相关。
单独使用主观疲劳评分量表不能作为运动障碍或疾病进展的指标，因为它会影响 MS 患者的行走能力。
