Gil-Peralta A, Alter M, Lai S M, Friday G, Otero A, Katz M, Comerota A J
Neuroepidemiology Section, Medical College of Pennsylvania, Philadelphia 19129.
Stroke. 1990 May;21(5):740-4. doi: 10.1161/01.str.21.5.740.
We compared carotid artery disease in 99 black and 106 white patients using duplex ultrasonography (B-mode imaging and Doppler spectral analysis). Blacks had significantly less stenosis of the extracranial internal carotid artery than whites. Among the risk factors investigated, hypertension alone, ischemic heart disease, diabetes mellitus, and smoking failed to explain the racial difference. Although carotid stenosis of greater than or equal to 40% correlated significantly with age in both races (p = 0.001 in whites and p = 0.005 in blacks), blacks had significantly less carotid stenosis of any degree even when age was taken into account. Multivariate analysis showed that race is a significant and independent risk factor for carotid stenosis (p less than 0.0001). Hypertension interacting with race was also significant. Our results require verification in population-based studies. Carotid duplex ultrasonography offers a noninvasive method for carrying out such studies.
我们使用双功超声检查（B 型成像和多普勒频谱分析）对 99 名黑人患者和 106 名白人患者的颈动脉疾病进行了比较。黑人颅外颈内动脉狭窄程度明显低于白人。在所研究的危险因素中，仅高血压、缺血性心脏病、糖尿病和吸烟并不能解释种族差异。尽管在两个种族中，颈动脉狭窄大于或等于 40%均与年龄显著相关（白人中 p = 0.001，黑人中 p = 0.005），但即便考虑年龄因素，黑人的任何程度颈动脉狭窄仍明显较少。多变量分析表明，种族是颈动脉狭窄的一个显著且独立的危险因素（p < 0.0001）。高血压与种族的相互作用也具有显著性。我们的结果需要在基于人群的研究中进行验证。颈动脉双功超声检查为开展此类研究提供了一种非侵入性方法。
