Department of Chemistry and Biochemistry, University of California, Los Angeles, 405 Hilgard Ave., Los Angeles, CA 90095, United States.
Bioorg Med Chem Lett. 2011 Oct 1;21(19):5842-8. doi: 10.1016/j.bmcl.2011.07.107. Epub 2011 Aug 4.
A structure-activity relationship (SAR) study was carried out to identify novel, small molecular weight compounds which induce readthrough of premature termination codons. In particular, analogs of RTC13, 1, were evaluated. In addition, hypothesizing that these compounds exhibit their activity by binding to the ribosome, we prepared the hybrid analogs 13 containing pyrimidine bases and these also showed good readthrough activity.
进行了一项结构-活性关系 (SAR) 研究，以确定能诱导提前终止密码子通读的新型小分子化合物。特别是，对 RTC13 的类似物 1 进行了评估。此外，基于这些化合物通过与核糖体结合发挥其活性的假设，我们制备了含有嘧啶碱基的混合类似物 13，它们也表现出良好的通读活性。
