Department of Chemistry, Veer Narmad South Gujarat University, Surat, Gujarat, 395007, India.
Mol Divers. 2022 Dec;26(6):3037-3045. doi: 10.1007/s11030-021-10363-8. Epub 2022 Mar 20.
A novel, simple and efficient protocol for the Fe-catalyzed, intermolecular cross-dehydrogenative coupling of pyrimidine bearing 4-thiazolidinones systems and terminal alkynes was established. This methodology offers a high yielding, straightforward, and one-pot approach towards the synthesis of alkynylated 4-thiazolidinones without prior activation of C(sp)-H and C(sp)-H. The results of control experiments indicated that this conversion might proceed via a radical process.
建立了一种新颖、简单、高效的 Fe 催化嘧啶取代 4-噻唑烷酮体系与末端炔烃分子间交叉脱氢偶联反应的新方法。该方法提供了一种高产、直接、一锅法合成炔基取代 4-噻唑烷酮的方法，无需预先激活 C(sp)-H 和 C(sp)-H。控制实验的结果表明，这种转化可能是通过自由基过程进行的。
