Department of Biochemistry, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonan-ku, Fukuoka, 814-0180 Japan.
Anticancer Res. 2011 Jul;31(7):2425-9.
The low-intensity ultrasound that is used in clinical diagnoses, such as abdomen echo inspection, is a non-invasive treatment, and penetrates deeper into the body than light. Recently, sonodynamic therapy (SDT), which uses low-intensity ultrasound together with a sonosensitizer, has been developed for cancer therapy in applying such properties of ultrasound. So far, most sonosensitizers that have been developed are sensitive to light as well as ultrasound, implying that the shortcomings of photosensitizers used during photodynamic therapy, such as skin sensitivity, still need to be overcome in SDT. Some exceptions were, however, reported in recent studies in which sensitizers were activated mainly by ultrasound but not by light. Furthermore, recent in vivo studies have demonstrated that SDT with a sonosensitizer has a great potential as a non-invasive and repeatable treatment for cancer therapy.
用于临床诊断（如腹部超声检查）的低强度超声是一种非侵入性治疗方法，其穿透深度比光更深。最近，人们利用超声的这些特性，开发出了声动力学疗法（SDT），将低强度超声与声敏剂联合用于癌症治疗。到目前为止，大多数开发出的声敏剂对光和超声都很敏感，这意味着在声动力学疗法中仍需要克服光动力疗法中使用的光敏剂的缺点，如皮肤敏感性。然而，最近的一些研究报告了一些例外情况，其中敏化剂主要通过超声而不是光激活。此外，最近的体内研究表明，使用声敏剂的声动力学疗法作为一种非侵入性和可重复的癌症治疗方法具有很大的潜力。
