Carter D R, Beaupré G S
Department of Mechanical Engineering, Stanford University, CA.
J Bone Miner Res. 1990 Mar;5 Suppl 1:S177-84. doi: 10.1002/jbmr.5650051372.
Bone mass and architecture in appendicular and most axial sites is controlled primarily by the tissue-loading history. We introduce a conceptual framework for understanding how fluoride treatment alters this control and can cause systemic increases in bone mass. Due to possible adverse influences of fluoride on the mineralized tissue physical characteristics, however, the increase in bone mass does not necessarily result in an increase in bone strength. Using engineering analyses of bone trabeculae, we calculate the losses in trabecular strength which can be caused by the presence of hypomineralized or hypermineralized fluorotic tissue. Significant increases in bone volume fraction and bone mass may be required to overcome these strength deficits.
四肢骨骼和大部分中轴骨骼部位的骨量和骨结构主要受组织负荷历史的控制。我们引入了一个概念框架，以理解氟化物治疗如何改变这种控制并导致全身骨量增加。然而，由于氟化物对矿化组织物理特性可能产生的不利影响，骨量增加并不一定会导致骨强度增加。通过对骨小梁进行工程分析，我们计算了低矿化或高矿化氟骨症组织的存在可能导致的骨小梁强度损失。可能需要骨体积分数和骨量显著增加才能克服这些强度缺陷。
