Department of Endocrinology and Metabolic Diseases, Harran University, Medical School, Sanliurfa, Turkey.
Clin Appl Thromb Hemost. 2012 Jun;18(3):312-5. doi: 10.1177/1076029611416348. Epub 2011 Aug 25.
Mean platelet volume (MPV) was studied in subclinical hypothyroidism (SH) and the results are conflicting. The aim of this study is to assess how MPV is affected in overt hypothyroidism (OH) and mild SH, the 2 end points of hypothyroidism, in patients having low cardiac risk. Premenopausal women without any cardiac risk, 18 with OH, 30 with mild SH, and 37 euthyroid controls were enrolled. Overt hypothyroidism group had higher low-density lipoprotein cholesterol (LDL-C) and total cholesterol levels than the control group (P < .001 and P < .05, respectively). Increase in MPV was insignificant in OH group when compared with SH and control groups. No correlation was observed between MPV and metabolic and hormonal parameters. Both OH and SH did not influence MPV and high-sensitivity C-reactive protein (hs-CRP) in patients with low cardiovascular risk, but these findings need to be further evaluated in this patient group.
血小板平均体积 (MPV) 在亚临床甲状腺功能减退症 (SH) 中的研究结果存在争议。本研究旨在评估在甲状腺功能减退症的两个终点，即显性甲状腺功能减退症 (OH) 和轻度 SH 中，MPV 在低心脏风险患者中的变化情况。本研究纳入了无任何心脏风险的绝经前女性，其中 18 例患有 OH，30 例患有轻度 SH，37 例甲状腺功能正常。OH 组的低密度脂蛋白胆固醇 (LDL-C) 和总胆固醇水平均高于对照组（分别为 P <.001 和 P <.05）。与 SH 和对照组相比，OH 组的 MPV 增加不显著。MPV 与代谢和激素参数之间无相关性。在低心血管风险患者中，OH 和 SH 均不影响 MPV 和高敏 C 反应蛋白 (hs-CRP)，但这些发现需要在该患者群体中进一步评估。
