硫氧还蛋白 1 的过表达主要延长了小鼠寿命的早期部分。
Thioredoxin 1 overexpression extends mainly the earlier part of life span in mice.
机构信息
Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1286-99. doi: 10.1093/gerona/glr125. Epub 2011 Aug 26.
Abstract
We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1)(+/0)]. The Tg(TRX1)(+/0) mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1)(+/0) mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1)(+/0) mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1)(+/0) mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1)(+/0) mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.
摘要
我们研究了过表达硫氧还蛋白 1（Trx1）的转基因小鼠中 Trx1 水平升高对氧化应激和衰老的影响 [Tg（TRX1）（+/0）]。与野生型同窝仔相比，Tg（TRX1）（+/0）小鼠在所有检测的组织中 Trx1 蛋白水平明显升高。与野生型同窝仔相比，Tg（TRX1）（+/0）小鼠的肝脏中蛋白质氧化损伤和脂质过氧化水平明显降低。生存研究表明，雄性 Tg（TRX1）（+/0）小鼠与野生型同窝仔相比，显著延长了早期寿命，但雌性小鼠没有观察到明显的寿命延长。雄性和雌性 Tg（TRX1）（+/0）小鼠的最大寿命均未发生变化。我们的研究结果表明，Tg（TRX1）（+/0）小鼠中 Trx1 水平的升高与对氧化应激的抵抗力增强有关，这可能在生命早期有益，但对 C57BL/6 小鼠的最大寿命没有影响。
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