Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA.
J Gerontol A Biol Sci Med Sci. 2011 Dec;66(12):1286-99. doi: 10.1093/gerona/glr125. Epub 2011 Aug 26.
We examined the effects of increased levels of thioredoxin 1 (Trx1) on resistance to oxidative stress and aging in transgenic mice overexpressing Trx1 [Tg(TRX1)(+/0)]. The Tg(TRX1)(+/0) mice showed significantly higher Trx1 protein levels in all the tissues examined compared with the wild-type littermates. Oxidative damage to proteins and levels of lipid peroxidation were significantly lower in the livers of Tg(TRX1)(+/0) mice compared with wild-type littermates. The survival study demonstrated that male Tg(TRX1)(+/0) mice significantly extended the earlier part of life span compared with wild-type littermates, but no significant life extension was observed in females. Neither male nor female Tg(TRX1)(+/0) mice showed changes in maximum life span. Our findings suggested that the increased levels of Trx1 in the Tg(TRX1)(+/0) mice were correlated to increased resistance to oxidative stress, which could be beneficial in the earlier part of life span but not the maximum life span in the C57BL/6 mice.
我们研究了过表达硫氧还蛋白 1（Trx1）的转基因小鼠中 Trx1 水平升高对氧化应激和衰老的影响 [Tg（TRX1）（+/0）]。与野生型同窝仔相比，Tg（TRX1）（+/0）小鼠在所有检测的组织中 Trx1 蛋白水平明显升高。与野生型同窝仔相比，Tg（TRX1）（+/0）小鼠的肝脏中蛋白质氧化损伤和脂质过氧化水平明显降低。生存研究表明，雄性 Tg（TRX1）（+/0）小鼠与野生型同窝仔相比，显著延长了早期寿命，但雌性小鼠没有观察到明显的寿命延长。雄性和雌性 Tg（TRX1）（+/0）小鼠的最大寿命均未发生变化。我们的研究结果表明，Tg（TRX1）（+/0）小鼠中 Trx1 水平的升高与对氧化应激的抵抗力增强有关，这可能在生命早期有益，但对 C57BL/6 小鼠的最大寿命没有影响。
