全血输注治疗急性有机磷中毒 1 例报告
Whole blood transfusion in the treatment of an acute organophosphorus poisoning--a case report.
机构信息
Department of Anaesthesiology and Intensive Therapy, Karolinska University Hospital, Stockholm, Sweden.
出版信息
Med Sci Monit. 2011 Sep;17(9):CS109-11. doi: 10.12659/msm.881922.
Abstract
BACKGROUND
Organophosphorus compounds (OP) are a group of substances used in agriculture as pesticides and are also used as military poisoning agents (MPA). Intoxication by these agents may cause severe systemic disturbances related to both the exposure time and lethal agent concentration. Toxic effects result from an excess of the endogenous neurotransmitter, acetylcholine (ACh), because decomposition of Ach by cholinesterases is blocked by OP.
CASE REPORT
The authors describe a case in which an acute OP poisoning was managed both conventionally and with cholinesterase substitution by blood transfusion.
CONCLUSIONS
Whole blood transfusion could be beneficial in the treatment of these life-threatening medical conditions.
摘要
背景
有机磷化合物（OP）是一组在农业中用作杀虫剂的物质，也被用作军用毒剂（MPA）。这些物质的中毒可能会导致严重的全身紊乱，这与暴露时间和致死剂浓度有关。毒性作用是由于内源性神经递质乙酰胆碱（Ach）的过量引起的，因为 Ach 被 OP 分解被胆碱酯酶所阻断。
病例报告
作者描述了一个急性 OP 中毒的病例，该病例采用常规治疗和通过输血进行胆碱酯酶替代治疗。
结论
全血输注可能对治疗这些危及生命的疾病有益。
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